10        20        30        40        50        60        70        80        90       100       110       120                    
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                                                                                        
Cryptosporidium parvum   MSVLKGALAVLMKQEVLTLGEYLEQKRKIRVFKEEGLYNDSSGELRRLLEETLILEDPSIPKALKEGFLGLRELTFNSLDNSLDINGDRRKLLGINIEKLLEWSSILGQNYFSSPRNQSS 
Cryptosporidium hominis  MSVLKGALAVLMKQEVLTLGEYLEQKRKIRVFKEEGLYNDSLGELRRLLEKTLILEDPFMPKALKEGFLGLRELTFNSLDNSLDINGDRRKLFGINIEKLLEWSSILGQNYFSSPRNQSS 
Giardia lamblia          ------------------------------------------------------------------------------------------------------------------------ 
Giardia intestinalis     ------------------------------------------------------------------------------------------------------------------------ 
Leishmania amazonensis   -----------------------------------------------------------------------------------------MSASFPSIPGFAGPLSLKAFLEEYFGLHLTF 
Leishmania infantum      -----------------------------------------------------------------------------------------MSASFPSIPGFAGPLSLKAFLEEYFGLHLTF 
Trypanosoma brucei       -----------------------------------------------------------------------------------------MAQMFPSVPGYDGPFSLKDFLHNYIGLQLRW 

                                 130       140       150       160       170       180       190       200       210       220       230       240           
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                   |-------------------------------------------------------------------------------------------------Mo 
Cryptosporidium parvum   MSSGKRSRNTEYNETLSPSFITD-QIKNIIPDSEKDS-----------------------------------------------------LTYQVQDFELLLRK--HFPRIRIFHS-GSY 
Cryptosporidium hominis  MSSGKRSRNNEYNETLPPSFITD-QIKNIIPDSEKDS-----------------------------------------------------PTYQVQDFELLLRK--HFPRIRIFHS-GSY 
Giardia lamblia          --------------------MDFPLSLLDANVSKAIF-----------------------------------------------------ILLQGEPEQASLWS--LILQLRTPGQ-GSS 
Giardia intestinalis     --------------------MDFPLSLLDANVSKAIF-----------------------------------------------------ILLQGEPEQASLWS--LILQLRTPGQ-GSS 
Leishmania amazonensis   AAETASPSPRAAATAETPSAAG-FRALRDVVLPPNQSFLVVVYVALHASSSPPPTTAHASPTPATPDPGCAAPPTGLGRLRQPLAHQTAVSTAHDTCVTRCNPSDRQNPFCLSSSSTGKN 
Leishmania infantum      AVETASPSPRAAAAAEAPSAAG-FRALRDVVLPPNQSFLVVVYVALHASSSPPPTTAHASPTPPTPAPGCAASATGFGRLRQPLTHQTAASTAHDTYVARCSPADRPNSSCSSSSSTGKN 
Trypanosoma brucei       STPQENSTTLPPSNSN-----------VVVVPPTGNFHVVVYVSRSAPPP----------------------------------QRSVRSVAVLSSC----------------------S 

                                 250       260       270       280       290       300       310       320       330       340       350       360           
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures               tif GQ--------------------------------------------------------------------------------------------|                      
Cryptosporidium parvum   SGLRTSFDTIKPKKYSFCN---STLYKFQ-NLHAWNT-----LLSKI-GPIEILFLFVCCIIFRILGDHSE-ILIQQAGRMLTNDFLEELARLYETGPK--KTNSFVSSSSLTPILTIEE 
Cryptosporidium hominis  SGLRTSFDTIKHKKYSFCN---STSYKFQ-NLHAWNT-----LLSKI-GPIEILFLFVCCIIFRILGDHSE-ILIQQAGRMLTNDFLEELARLYETGPK--KTNSFVSSSSLTPILTIEE 
Giardia lamblia          FASCA-----------------SLIYKDLKGLSSWIT-----EAAFI-PFLRRLGFCSLYLSYG---HDVL-LELFKYPIVLTSTVSGKRVLLSEPQMP--------------------- 
Giardia intestinalis     FASCA-----------------SLIYKDLKGLSSWIT-----EAAFI-PFLRRLGFCSLYLSYG---HDVL-LELFKYPIVLTSTVSGKRVLLSEPQMP--------------------- 
Leishmania amazonensis   GNARSPWCASASWLLYTNTSHRPFTDALLRHP--WRASFSACLGPAAMGFIE-MY----CPIVLQLEAMAGGVQVIGPALKHVALETSFSATAQLSEMKGLPPRGSASVSSRGVKRAVDT 
Leishmania infantum      GNARGLWRSSAFWLLYTNTSHRPLTDALLRHP--WWASFAACLGPAAMGFIE-MY----CPIVLQLEAMAGGVQVLGPALKHAALETSFSATAPSSEMKGPPPQGSGYVSSRGVKRAVDT 
Trypanosoma brucei       NKMDG---DHPQPSVPTHFHGRPLTSSVLKHP--FWDALFSQIGPTAVSFIV-LW----APIVVQFEASGGGLQVLGPPLKR-----------------SASCAVKRQPGAG-------- 

                                 370       380       390       400       410       420       430       440       450       460       470       480           
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                                                                                        
Cryptosporidium parvum   KEEVKPLDETPRQVNKRSGGIIKDSRLSKIYKIDIPYRSTFLYCDHFSKRGGLPCLSVLRLLPPNLLGARTLLRFIIQTDHIFKDHNRQSLIGLLGSYEMTKFSRVKCKLASAMMEEFQN 
Cryptosporidium hominis  KEEVKPLDETPRQVNKRSGGIIKDSRLSKIYKIDIPYRSTFLYCDHFSKRGGLPCLSVLRLLPPNLLGARTLLRFIIQTDHIFKDHNRQSLIGLLGSYEMTKFSRVKCKLASAMMEEFQN 
Giardia lamblia          ---------------------------------------------------------------LAFPPCLHDKSVSSMVRASTVQYASNCLEEFISMIQEHPMNVRFIFFCKTRPYIRAF 
Giardia intestinalis     ---------------------------------------------------------------LAFPPCLHDKSVSSMVRASTVQYASNCLEEFISMIQEHPMKLRFIFFCKTRPYIRAF 
Leishmania amazonensis   GE-CSAPLPLQKQRRVEAVASPPKAGRRLQREVAPSHRPCRDDSFSSPVNRAAMPATWAAALTRTDDPRTRLYSVRVSDSDCTGDG-GGALPLPAGSLEAHWLPRHPRSLHRVLQAALPK 
Leishmania infantum      GE-CSGFLPLQKQRRVEAPP-KAKAGRRLQRGVVPCSRPRRDDPFASPVNRAAMPVTWAAALTRTDVPRTRLYSVRVSDSDGAGDGSGGALPLPAGFLEAQWLRRHPHSLHRVLQAALPK 
Trypanosoma brucei       ---WWEGKLKVSRTETLTQND---------------------------PHCFCIEGTSSPVALYRLNVPRLHLVEQSPLRST------ADARHAVTLILEQLWIEHHKSSCSPSSDRDIS 

                                 490       500       510       520       530       540       550       560       570       580       590       600           
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                                                |--------------Motif CP---------- ----- 
Cryptosporidium parvum   L--------------------------------------------------------------------------------LLNI------------RN-TSP-VN-FLD---QI-CPIE 
Cryptosporidium hominis  L--------------------------------------------------------------------------------LLNI------------RN-TSP-VD-FLG---QI-CPIE 
Giardia lamblia          HSLALLGSATAIWHLSLLPSQCLTAFYQANPLVTFKFPYNAFSTRSFSSLLQLCTSRGRLMPNNAINSNAKARITRLISIFRSKM------------KR-LSHNLT-FL----KD-KKPQ 
Giardia intestinalis     HSLALLGSATAIWHLSLLPSQCLTAFYQANPLVTFKFPYNAFSTRSFSSLLQLCTSRGRLMPNNAINSNAKARITRLISIFRSKM------------KR-LSHNLT-FL----KD-KKPQ 
Leishmania amazonensis   RAAYGASTRHYCAGTGERGTGCTSVKNISMWHVAHVFRWLV----------------------------------------LQPSQSGEVAFQTTSPKFDLPSYLRRFLSTDVDQ-CSRL 
Leishmania infantum      RVAYGASARRYSVGASERVTGCTSVEDIPMWHVAHVFRWLV----------------------------------------LQPPQSGADASPTTPPKFDLPSYLRRLLSTVVDQ-CSRL 
Trypanosoma brucei       QRLCG------VATGSATNCCGDSCVVLAQARNQVNAV-------------------------------------------FPYTL-LPVHDDAVSGNGTVKEYLIHVLHCALGSVC-RM 

                                 610       620       630       640       650       660       670       680       690       700       710       720           
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures               |                                                    |--------------------------Motif QFP------------------------------- 
Cryptosporidium parvum   PIKDSDLQNFNKL----------------------------------------PIPCFETSSTRVVNF-------LRLYLIKVLPKNILGTFKNFKTFINKKIPIIVNLHIRETFKIQHA 
Cryptosporidium hominis  PIRDSDLQNFNKL----------------------------------------PIPCFETSSTRVVNF-------LRLYLIKVLPKNILGTFKNFKTFINKKIPIIVNLHIRETFKIQHA 
Giardia lamblia          SLLQSFGFDTHFRVFLDE-----------TGTL--------------------RHAPLPLSVHKITLY-------LMLYCKSISAFSILG-KRNARTFH-SHLFRFISQPMNGFMTLQEL 
Giardia intestinalis     SLLQSFGFDTHFRVFLDE-----------TGTL--------------------RHAPLPLSVHKITLY-------LMLYCKSISAFSILG-KRNARTFH-SHLFRFISQPMNGFMTLQEL 
Leishmania amazonensis   DLRGAALRHTGYLEEAFR--------RQQQGVEPWDVQRL---STPVDVVVS--YLRTLLPTLRWAPL-------KEANNGLFWGRDAAGSERVLDALM-RAVRGWLIAGRQAVVPVSRF 
Leishmania infantum      DLRGAALKHTGYLEEAFR--------RQQQGVEPWDVQRL---STPVDVVVS--YLRTLLSTLRWAPL-------KEAKNRSFWGRDAAGSERVLDALM-GAVRNWLIAGRHAIVPVSRF 
Trypanosoma brucei       NIRGAAIKHTEFLEKRGKSVTSISQKAQTAGQENKMRAIPVGELTVPEPVVAS-YLETLFNMMWWRVPPRFVGGAVTADRVKFWGEEGT----VLTRLR-EVTVDWLCCGRHEVFLLSHF 

                                 730       740       750       760       770       780       790       800       810       820       830       840           
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures               ------------|                                                     |----------------------Motif T------------------------ 
Cryptosporidium parvum   MNGIEVSN--WVNRILEEKSYQFIKESKNLINSNQRSKKVPNNKTRSSIKKSLISLGKTYLARNIYFL-IVYLVFP-----ILRRHF----YATEIE-GSNKV-----RYFRHPVWIKIV 
Cryptosporidium hominis  MNGIEVSN--WVNRILEEKSYQFIKESKNLINSNQRSKKVPNNKTRSSIKKSLISLGKTYLARNMYFL-IVYLVFP-----ILRRHF----YATEIE-GSNKV-----RYFRHPVWIKIV 
Giardia lamblia          TSSISTKEF--L-LPATTVSKAEGEVRHHLLAYFVV------------------------------YL-MDFVILP-----ALYQSFSAVSMHTELSNRIETANSMVPALLSRSLWVSYK 
Giardia intestinalis     TSSISTKEF--L-LPATTVSKAEGEVRHHLLAYFVV------------------------------YL-MDFVILP-----ALYQSFSAVSMHTELSNRIETANSMVPALLSRSLWVSYK 
Leishmania amazonensis   LDGVPVAQVPWL-NGFYTTTPSLPFSDATSSASRHARRERSQVQQRV-------------------WLQFVLFLTQDILPFLLRASF----TITWSSKNTHKL-----LFFPAFVWRRLV 
Leishmania infantum      LDGVPVAQVPWL-NGFYTTTPSLPFSAATSSAARHARRERSHVQQRV-------------------WLQFVLFLTQDILPFLLRASF----TITWSSKNTHKL-----LFFPAFVWRRLI 
Trypanosoma brucei       LDGVPVSRIPWL-RGFYTKEP-----------ARKRRSMIQQRV----------------------FLQLVLFLYQCVVPFLIRRSF----HVACTSKSPYIF----FFIPRAVWVRLTR 

                                 850       860       870       880       890       900       910       920       930       940       950       960           
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures               --------|                                                                                            |--1-||---2--|      
Cryptosporidium parvum   RQADKWYLESILKGIQSKDYIMNLSSIQEISKLIDKNSEFSENIPK-------------------------------------------------------IRWVPKSKGLRPLINLSKV 
Cryptosporidium hominis  RQADKWYLESILKGIQSKDYIMNLSSIQEISKLIDKNSEFSENIPK-------------------------------------------------------IRWIPKSKGLRPLINLSKV 
Giardia lamblia          NYLIKSSARLEIAATYEFVCSLSNLHSIPLTNEDAVNRIFWKQVSPGR-----------------------------------------------------LSFVYKSNGRVRPLCNFSF 
Giardia intestinalis     NYLIKSSARLEIAATYEFVCSLSNLHSIPLTNEDAVNRIFWKQVSPGR-----------------------------------------------------LSFVYKSNGRVRPLCNFSF 
Leishmania amazonensis   RREVRRTRSCHAPRSQMSLAEERTRMSGADHAALVSAPNACGGAVAAAFPSPHSAASNASAAISAPRDEWRAVRTGGALAHWSARATLATRGGGASCLYAGVRFRPDRRKLRPIAVVRSA 
Leishmania infantum      RREVRRTRSCGAPRSQMPLAGESARSVGAERVALSSAPCACEGAATAALPTPHSAASKASAAISAPRDVWRAVRTDGVLAHRGARATLATRGGGASCLYASVRFRPDRRKLRPIAVVRSA 
Trypanosoma brucei       REMRRVCIRRVKRMRSDTLSDPQMRGHAGLPPMALERVTSEGLMQLIGPSSQPVGDDS----------GGVSDVCKLRDSSSPLLYSD-------------VRFLVDGSKLRPIARPRFG 

                                 970       980       990       1000      1010      1020      1030      1040      1050      1060      1070      1080          
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                                                                                        
Cryptosporidium parvum   GSGQILQQNLERDHTCEEKKKIGFCDCNSVWTGGDLPTSWINNNYYYNYFNSNGNNGIVGNNHNYGHINNIGGKNFTSFSSQNCQIMTPPGRLGVGLGFGNYNIGIGINSGSSVPTTPIN 
Cryptosporidium hominis  GSGQILQQNLERDHTCEEKKKIGFCDCNSVWTGGDLPTSWINNNYYYNYYNSNGNNGTVGNNHNYGHINNIGGKNFTSFSSQNCQIMTPPGRLGVGLGFGNYNIGIGINSGSSVPTTPIN 
Giardia lamblia          CSRRHRVS----LNSFLRSALQVIIFELERP-------------RNRYLQAHLAKNLGHIAVDY-----------AAWLDATY------TENPE-------------------------- 
Giardia intestinalis     CSRRHRVS----LNSFLRSALQVIIFELERP-------------RNRYLQAHLAKNLGHIAVDY-----------AAWLDATY------TENPE-------------------------- 
Leishmania amazonensis   SLRSLKEMARGSPSPYSHASAIVRLLRRLGCSDADGQLPAATATLLRQVQARSRHNRRTGVHRSAHPLPPHLPHKAALQDALRCLVSGVEEQRVRDGLPRLSNLSHQDEYAELRSFCEEV 
Leishmania infantum      SLRSLKEMARGSPSPYSHASAIVRLLCRLGCSDTDGQLPAATATLLRRVQARSRHNHHTGVHRFPHPLPPHLPHKAALRDALRCLVSGVEEQRVRDGLPRLSNLSHQDEYAELRSFCEEV 
Trypanosoma brucei       WQRSLLKAADG---------------------------VGSSTLASALAKAGKYLATDGKAMWPS-------PNSAVLRDALRCLDAGVEER----------RITTGARQRAIGSHNDEY 

                                 1090      1100      1110      1120      1130      1140      1150      1160      1170      1180      1190      1200          
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                                                    |--------------Motif A------------- 
Cryptosporidium parvum   KVMRRPSSNRIIDIRRPSTNNMLFYPSKILRSFLLRMTGKNHLGASLVQFGDIYKIIKNWWIKNRRDKQQFQMNEDFYQNQGKKMSHVK---IYIIKADLVNCFENINKSKIFEFLD-VI 
Cryptosporidium hominis  KVMRRPSSNRIIDIRRPSTNNMLFYPSKILRSFLLRMTGKNHLGASLVQFGDIYKIIKNWWIKNRRDKQQFQMNEDFYQNQGKKMSHVK---IYIIKADLVNCFENINKSKIFEFLD-VI 
Giardia lamblia          ------------------------------------------------------------------------------------------AQIYMVTTDMITAFESVSVPRLLYYISHYI 
Giardia intestinalis     ------------------------------------------------------------------------------------------AQIYMVTTDMITAFESVSVPRLLYYISHYI 
Leishmania amazonensis   RGRHAIPCEGPAKTTPAVSSASPPGA-----------------------------------------------------------TACFAPYVTLLRSDASRCYDNLPQGRVLAAVRSLV 
Leishmania infantum      RRRPALPCEGPAGTAPVVSSASPPSAA----------------------------------------------------------ACCFAPYVTLVRSDASRCYDNLPQERVLAAVASLV 
Trypanosoma brucei       IEVRSFIQCARQFCTIPTLVQGETSAA----------------------------------------------------------LLADATAVTMVRGDAARCYDHLPQEAVVNIMRGLV 

                                 1210      1220      1230      1240      1250      1260      1270      1280      1290      1300      1310      1320          
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures               ---|                                                                                                                     
Cryptosporidium parvum   SLPNEISLLSLYSRALSKTTIIPPFDNMNRDSYQDELGRSCIITSKGKLNMVPIFEKDHDEDQKVVKSKIKRIIGPDLDELLWNLKNSCLSNKDLSILGQKKAEIFTFLNSRRVINWKLV 
Cryptosporidium hominis  SLPNEISLLSLYSRALSKTTIIPPFDNMNRDSYQDELGRSCIITSKGKLNMVPIFEKDHDEDHKVVKSKIKRIIGPDLDELLWNLKNSCLSNKDLSILGQKKAEIFTFLNSRRVINWKLV 
Giardia lamblia          VT--GNAYVVLTYKEIAPSKMPKIRTVALPCQHNGCVSMDSISRYLLCKETPKKQPNSMLCPMHARIYKREDIIK-----MLELHLLNP------------------------------- 
Giardia intestinalis     VT--GNAYVVLTYKEIAPSKMPKIRTVALPCQHNGCVSMDSISRYLLCKETPKKQPNSMLCPMHARIYKREDIIK-----MLELHLLNP------------------------------- 
Leishmania amazonensis   KH--DAYRVLRFTVIHAVDSEATCKGGCLLRRTFTTRTIPCAEAECGFLARIPRGHIYWEEE-GRTPT-GPHTSAAVSRTTDASSRCGANLISGAAVRA--------------------- 
Leishmania infantum      KH--DAYRVLRFTAIHALDGEAACKGGCLLRRTFTTRTIACAEAECGVLARIPRGHIYWEEEEEGRTLSGPHTTAAVSRTTKASSRCGANLISGAAVRA--------------------- 
Trypanosoma brucei       TH--ETYYSLKLTVVTLTTVKNVSKKT-----------RSSHAESQLSSMKETNGSTVKHRKLQLSKRVKLVPGRYVQEG-VLYGIARGCIAYEEQSVGSDSLVSGEEIRS--------- 

                                 1330      1340      1350      1360      1370      1380      1390      1400      1410      1420      1430      1440          
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                      |---------------------------Motif B'---------------------|                                        
Cryptosporidium parvum   KEIIKIHLNTSFFRLRTCSKSLRLIKSKQLGNSIKFGKRFLSLFKQDFGIPQGSSISYILCCLYYNFLDLNPEIQNLLGHSFFSSSYISLSFLNPIKQEKVQLLDPTEKDLFSQHDLETG 
Cryptosporidium hominis  KEIIKIHLNTSFFRLRTCSKSLRLIKSKQLGNSIKFGKRFLSLFKQDFGIPQGSSISYILCCLYYNFLDLNPEIQNLLGQSFFSSSCISLSFLNPIKQEKAQVLDPTKKDLFSQHDLETG 
Giardia lamblia          --------------------------------LVIHEGGV---YRLTSGIPQGSVVSTVLFNCYSSLLHVQLLNTGIVSSRL-------------------------------------- 
Giardia intestinalis     --------------------------------LVIHEGGV---YRLTSGIPQGSVVSTVLFNCYSSLLHVQLLNTGIVSSRL-------------------------------------- 
Leishmania amazonensis   -----------------------LLSEHIRHHLVVVSGG--SLFEQRVGILQGSPVAMLLCDRLFSNVVDTALSSILSEHAER------------------------------------- 
Leishmania infantum      -----------------------LLSEHLRHHLVVVSGG--NLLEQRVGILQGSPVAMLLCDRLFSDVVDTALSGILSEHAER------------------------------------- 
Trypanosoma brucei       -----------------------VLQKHLQSHLVMLNG-K--MYIQRMGINQGSAVAMLLCDQLLERV-DAALSSILSEHEEP------------------------------------- 

                                 1450      1460      1470      1480      1490      1500      1510      1520      1530      1540      1550      1560          
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                                          |-----------Motif C-------------|             
Cryptosporidium parvum   LSRYPEFKENEINIYNTSTSKKRRLEISEYNINAKSVLLQPSEEFNNNINNQNCQIRANLKSYDQESPSQSNKQESLLLRWVDDFLFLTSDLESAKKFLKLL-----YIQK-LWGSNVSK 
Cryptosporidium hominis  LSRYPEFKENEINIYNTSTSKKRRLEISEYNINAKSVLLQPSEEFDNNINNQNCQIRVNLKNYDQESPSQSNKQESLLLRWVDDFLFLTSDLESAKKFLKLL-----YIQK-LWGSNVSK 
Giardia lamblia          ---------------------------------------------------------------------------FFYRTFVDDWLLLTTSIALLDAYIEYLNIMRDHGAYFRLSCFTKP 
Giardia intestinalis     ---------------------------------------------------------------------------FFYRTFVDDWLLLTTSIALLDAYIEYLNIMRDHGAYFRLSCFTKP 
Leishmania amazonensis   ---------------------------------------------------------------------------SLLLRRVDDVLVATTSPAAAERCLRAM-----QRGWPSVGYLSNP 
Leishmania infantum      ---------------------------------------------------------------------------SLLLRRVDDVLVATTSPAAAERCLQAM-----QRGWPSVGYLSNP 
Trypanosoma brucei       ---------------------------------------------------------------------------ALLLRRVDDVLVVTLSRAAASRCEDAL-----RSGWSEIGFFCQE 
                                                                                                                       |-------------------Motif  

                                 1570      1580      1590      1600      1610      1620      1630      1640      1650      1660      1670      1680          
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                   |--------------------Motif E------------------------|                                                
Cryptosporidium parvum   DKINSNFPWIDHNNEIIILEEDDVLLSSP---------SSSCSSSCSSSSSSSSSSSSSS-SSSSSFPPSTE-CTSSPVEKRINTNKSEKDCQNEKEMINKAKIASKQFHKQVSWTGMKF 
Cryptosporidium hominis  DKINSNFPWIDHNNEIIIFEEDDVLLSSP---------SSSCSSSCSSSSSSSS-------SSSSSFPPSTE-CLSSPVEERTNTSKGEKDCQNEKEMINKAKIALKQFHKQVSWTGMKF 
Giardia lamblia          HKNSPFAPIATLDCSREPIPKKSLYTPNLNQDMYKLDVPRYCGYIFLEN-VAIIDVLKWFSSTRTNGSPSYPMIFGSGISVMQRLRLVFKKR---------------------------- 
Giardia intestinalis     HKNSPFAPIATLDCSREPIPKKSLYTPNLNQDMYKLDVPRYCGYIFLEN-VAIIDVLKWFSSTRTNGSPSYPMIFGSGISVMQRPRLVFKKR---------------------------- 
Leishmania amazonensis   SKLTLS------KACG---SLVP-----------------WCGLLLHDTTLEVSVEWRRIGVLLGSLRVGDPHYVHRGDYEPLYLTQRFLAVLQLRVA-PTALCGRMNSKTRQLQTFYEV 
Leishmania infantum      SKLTLS------TACG---SLVP-----------------WCGLLLHDTTLEVSVEWRRIGVLLASLRVGDPHYVHRGDHEPLYLTQRFLAVLQLRVA-PTVLCGRMNSKTRQLQTFYEV 
Trypanosoma brucei       EKLR-RV-----T-CG---QPVR-----------------WCGLLWDPVTLEFAVDWARLAKMMPYLAVRP--RTGCEPLLSSLRFIRILRLRTP----MTALCRQINSKSRVVQTLYEI 
                         D------------------|                                                                                                     

                                 1690      1700      1710      1720      1730      1740      1750      1760      1770      1780      1790      1800          
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                                                                                        
Cryptosporidium parvum   SSEYSYLNCMVSPWKNLEFICVMDTVTLTTKHQFTSNYSNFHRFKSTTISENLQKSNYMWSVLGIKLIRYFDFRIKNGLLYDCKINSLFTVSFKYNSTNNQPIN-                
Cryptosporidium hominis  SSEYNYLNCMVSPWKNLEFICVMDTVTLTTKHQFTSNYSNFHRFKSMTISENLQKSNYMWSVLGIKLIRYFDFRIKNGLLYDCKINSLFTVSFKYNSTNKQPIN---------------- 
Giardia lamblia          -----------------------------------------IRDLRCFIERSIQAPDPRIKVDGSILYAYIRAVTFCILCYTRNIRYSESLRTLLRSTFCSLKATVWRHSTSRAIFIHVS 
Giardia intestinalis     ---------IRDLRCFIERSIQAPDPRIKVDGSILYAYIRAVTFCILCYTRNIRYSESLRTLLR-----------------------STFCSLKATVWRHSTSRAIFIHVSKR-IILHVY 
Leishmania amazonensis   GLLWTRVVLEKVQEALPVARNCCVTVLLLRPLAVCVGR----------------------------------------LCRLLSRHQRFLAARQSACDVSAAEVRACVLTALHRTVQAKL 
Leishmania infantum      GLLWSRVVLEKVQEALPAARNRCVAVLLLHPLAVCVGR----------------------------------------LCRLLNRHQRFLAARKSACDVSAAEVRACVLTALHRTVQAKL 
Trypanosoma brucei       GLLWSRFFLDKLKANAAFFR--PHVRTILQPLALATAT----------------------------------------LRRLVRKHSFDLQRLGSFCDVTDVEVRLCISAALYHTLHQRL 

                                 1810      1820      1830      1840      1850      1860      1870      1880      1890      1900      1910      1920          
                         ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
structures                                                                                                                                        
Cryptosporidium parvum                                                                                                                            
Cryptosporidium hominis  -----------                                                                                                              
Giardia lamblia          KRIILHVYGHNPRIRGLLLGMLSR--------------------------------------                                                           
Giardia intestinalis     GHNPRIRGLLLGMLSR----------------------------------------------                                                           
Leishmania amazonensis   RVLQARTVRAMTAQSGRTQRGPSLKGRRNNFCSTKASSVGRKGCEQRRRGRNRRN-TRVCLRSFWWLTAAEVESQWRRSLGALYRAAPRPGEACGSTASSPSPAASASLLMEDGPLSMHA 
Leishmania infantum      RVLQARTVRVMTAQRGRTPRGTSLKGRQKPPCTNKASSAGCKYCERRRKGRNRRCSTRVCLRSFWWLAAAEVELQWRRSLGALHRAAPHPGEARGSTAPSLSPSASASLLMEDGPLSMHA 
Trypanosoma brucei       AFMIGR---------------MSSVGKKKFLILMTAVLKRKMGELGSRINRNNQMESSLPSAADLLLVEGGDGVVSRGLAAVRFRPVETVRFQGCATRSA-------------------- 

                                 1930      1940 
                         ....|....|....|....|
structures                                    
Cryptosporidium parvum                        
Cryptosporidium hominis                       
Giardia lamblia                               
Giardia intestinalis                          
Leishmania amazonensis   RALSATRLSQT          
Leishmania infantum      RALSATRLSQT          
Trypanosoma brucei       -----------